The project “Characterizing Disorders using High-Density Multielectrode Array Data” embarks on a pioneering exploration to elucidate the complex neurophysiological underpinnings of neurodevelopmental disorders (NDDs). By harnessing the capabilities of high-density multielectrode arrays (MEAs), this initiative meticulously analyzes the electrophysiological properties of cells derived from mouse primary neurons, human induced pluripotent stem cells (iPSCs), and organoids. This approach facilitates a comprehensive characterization of the disorders, allowing for the identification of distinctive patterns and mechanisms at the cellular level that contribute to the manifestation of NDDs. Through the integration of advanced electrophysiological techniques and diverse cellular models, the project aims to unravel the intricacies of neuronal circuit dysfunctions, offering potential pathways for the development of targeted therapeutic interventions.