The SCN2A gene encodes the neuronal sodium channel Nav1.2, which is critical for the electrical activity of many types of neurons. Mutations in the gene alter the properties of the NaV1.2 channel, disrupting the function of single neurons and potentially leading to abnormal neuronal circuitry. Ultimately, these effects lead to epilepsy and/or ASD in affected patients. In this project, we will explore how alterations to the NaV1.2 channel affect the function of single neurons. Using computational models that simulate neuronal activity, we will study how each variant modulates single neuron activity and then simulate different drugs to see if they can reverse those effects.